ART-AiDE (Antiretroviral Therapy - Aquisition & Display Engine)

Version 1.0, Dec 2006

ART-AiDE makes it possible to generate a permanent electronic and graphical record of a patient's antiretroviral treatment (ARV) history, plasma HIV-1 RNA levels, CD4 counts, and (when available) genotypic resistance data.

Submitted data can be reviewed and the underlying XML file can be saved on the Graphical Summary page. The XML file allows you to update a patient's profile and graphical summary without having to re-enter data. The XML schema ART-AiDE uses can be found below:
Save your work frequently because your entries are not stored on our servers after you exit ART-AiDE.

Please report any difficulties using ART-AiDE or desired features to us.

Soo-Yon Rhee
Tommy Liu
Steve Goldman
Jonathan M. Schapiro
Robert W. Shafer
for the Stanford HIV Database

Supported by an unrestricted educational grant from Hoffman-LaRoche.


Table of Contents

  1. Entry page
  2. Antiretroviral Therapy (ARVs)
  3. Antiretroviral Therapy (ARVs) Review
  4. Plasma HIV-1 RNA & CD4+ Lymphocytes (RNA/CD4)
  5. Graphical Summary
  6. Sequences
  7. HIV db Interpretation
  8. Save Data To Computer


Entry page

ART-AiDE is begun by entering data on a new patient or by uploading a file previously created by the ART-AiDE program. For example, when you save your work, it will be saved in as an XML file that you can store on your computer and update without having to re-enter data.

To start ART-AiDE for a new patient, press the button "Start" in the left grey box. The 'Record ID' is optional. However, if you plan to print the graphical output or to save the XML for future analyses, then it will be useful to enter a unique 'Record ID'.

To load previously entered data, press the button "Browse", choose the file on your computer and press the button "Load" in the right grey box. On pressing "Load", ART-AiDE will first check if the format of the file you upload is in the XML schema ( If the file is in the XML schema, the data in the file will be processed and loaded to ART-AiDE. The ART-AiDE schema is an open source schema that is being widely adopted for representing patient antiretroviral treatments, virus levels, CD4 counts, and drug resistance data. Although the ART-AiDE schema will be updated over time, a version control system guarantees that previously created files will always be readable and updatable to the most recent XML version.


Antiretroviral Therapy (ARVs)

ARV Regimen

The Antiretroviral Therapy (ARV) form is the first form encountered when entering new patient data.

Additional ARVs

Use the "Additional ARV" section to indicates drugs known to be received but for which the simultaneously administered drugs, the dates of administration, and the duration of administration are not known. Therefore, it is only necessary to enter the drug name. Entering the duration of therapy with the drug is optional.


After the ARV treatment history has been entered or updated, press "Continue" to go to a page where the treatment history can be reviewed graphically.

This form will be updated to allow users to enter investigational ARVs and to simplify the entering of fixed-dose combinations and boosted PIs.


Antiretroviral Therapy (ARVs) Review



Plasma HIV-1 RNA & CD4+ Lymphocytes (RNA/CD4)

Plasma HIV-1 RNA Level

CD4+ Lymphocyte count


We are developing a batch upload system for RNA levels and CD4 counts in a tab-delimited text file.


Graphical Summary

The graphical output illustrates the temporal relationship between the ARVs, plasma HIV-1 RNA levels and CD4 counts. The figure is updated as changes are made using the forms.

When genotype testing results was entered using the form "Add Sequence" (see the section "Sequence"), the test results will be shown as a list of major drug resistance mutations as below: a list of protease drug resistance mutations inside a purple rectangle; a list of RT drug resistance mutations inside a green rectangle.




HIV db Interpretation


Each row shows the inferred levels of resistance to individual FDA-approved ARVs according to as explained in the program release notes ( However, unlike the main program, it calculates scores for individual sequences as well as scores for multiple sequences obtained by pooling mutations observed at all time points. Note: This program does not consider ARV treatment history.


Save Data To Computer

The ARV treatment, RNA levels, CD4 counts and genotype testing results that have been entered can be saved on your computer as a XML file. On pressing the button "Save Data to Computer", the data will be downloaded to your browser. Select "Save As" under the File menu on the browser to save the data on your computer as a file. Specify the name of file with a ".xml" extension. Once the data saved in a file, you can resume the ART-AiDE by uploading the file on the "Entry page". In this way, you can update a patient's profile and graphical summary without having to re-enter data.